Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

Dendritic cells (DCs) are crucial for priming of naive CD8(+) T lymphocytes to exogenous antigens, so-called “cross-priming.” We report that exogenous protein antigen can be conserved for several days in mature DCs, coinciding with strong cytotoxic T lymphocyte cross-priming potency in vivo. After M...

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Detalhes bibliográficos
Main Authors: van Montfoort, Nadine, Camps, Marcel G., Khan, Selina, Filippov, Dmitri V., Weterings, Jimmy J., Griffith, Janice M., Geuze, Hans J., van Hall, Thorbald, Verbeek, J. Sjef, Melief, Cornelis J., Ossendorp, Ferry
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672553/
https://ncbi.nlm.nih.gov/pubmed/19346487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900969106
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