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Selective Regulation of TCR Signaling Pathways by the CD45 Protein Tyrosine Phosphatase During Thymocyte Development

In CD45 deficient animals there is a severe defect in thymocyte positive selection, resulting in an absence of mature T cells and the accumulation of thymocytes at the double positive stage of development. However, the signaling defect(s) responsible for the block in development of mature single pos...

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Detalhes bibliográficos
Main Authors: Falahati, Rustom, Leitenberg, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671959/
https://ncbi.nlm.nih.gov/pubmed/18941197
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