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Complex topology rather than complex membership is a determinant of protein dosage sensitivity
The ‘balance hypothesis' predicts that non-stoichiometric variations in concentrations of proteins participating in complexes should be deleterious. As a corollary, heterozygous deletions and overexpression of protein complex members should have measurable fitness effects. However, genome-wide...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671925/ https://ncbi.nlm.nih.gov/pubmed/19293832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2009.9 |
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