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Total Synthesis of (±)-Agelastatin A, A Potent Inhibitor of Osteopontin–Mediated Neoplastic Transformations
[Image: see text] A stereoselective synthesis of agelastatin A, a potent cytotoxin and inhibitor of osteopontin (OPN)–mediated neoplastic transformations, has been accomplished in 14 steps (12 operations) with an approximate overall yield of 8%. Notable features of this route include the direct mann...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671850/ https://ncbi.nlm.nih.gov/pubmed/19228041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900133v |
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