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Diastereoselective Nitrenium Ion-Mediated Cyclofunctionalization: Total Synthesis of (+)-Castanospermine

[Image: see text] The asymmetric total synthesis of the α-glucosidase inhibitor (+)-castanospermine is reported. The central theme in our approach to this polyhydroxylated alkaloid is the simultaneous generation of the piperidine ring and the C-1/8a erythro stereodiad through the diastereoselective,...

詳細記述

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書誌詳細
主要な著者: Bowen, Edward G., Wardrop, Duncan J.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980585/
https://ncbi.nlm.nih.gov/pubmed/20964285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol102371x
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