The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer’s Disease Hippocampus

Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response called the unfolded protein response (UPR) that protects the cell against the toxic buildup of misfolded proteins. Previously, we reported that UPR activation is increased in Alzheimer’s disease (AD)...

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Hauptverfasser: Hoozemans, Jeroen J.M., van Haastert, Elise S., Nijholt, Diana A.T., Rozemuller, Annemieke J.M., Eikelenboom, Piet, Scheper, Wiep
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671357/
https://ncbi.nlm.nih.gov/pubmed/19264902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080814
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