A Rapid and Reliable Test for BRCA1 and BRCA2 Founder Mutation Analysis in Paraffin Tissue Using Pyrosequencing

The founder mutations in BRCA (BRCA1*185delAG, BRCA1*5382insC, and BRCA2*6174delT) account for 95% of the detectable BRCA mutations in breast and ovarian cancer families of Ashkenazi Jewish ancestry. Optimal clinical management of individuals from these high-risk families relies on the identificatio...

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Detalhes bibliográficos
Main Authors: Zhang, Liying, Kirchhoff, Tomas, Yee, Cindy J., Offit, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671333/
https://ncbi.nlm.nih.gov/pubmed/19324993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2009.080137
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