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Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
BACKGROUND: Germline inactivating mutations in BRCA1 and BRCA2 underlie a major proportion of the inherited predisposition to breast and ovarian cancer. These mutations are usually detected by DNA sequencing. Cost-effective and rapid methods to screen for these mutations would enable the extension o...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
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BioMed Central
2008
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2266761/ https://ncbi.nlm.nih.gov/pubmed/18298804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-59 |
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