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Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis

BACKGROUND: Germline inactivating mutations in BRCA1 and BRCA2 underlie a major proportion of the inherited predisposition to breast and ovarian cancer. These mutations are usually detected by DNA sequencing. Cost-effective and rapid methods to screen for these mutations would enable the extension o...

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Detalhes bibliográficos
Main Authors: Takano, Elena A, Mitchell, Gillian, Fox, Stephen B, Dobrovic, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266761/
https://ncbi.nlm.nih.gov/pubmed/18298804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-59
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