Detection of BRCA1 and BRCA2 Ashkenazi Jewish Founder Mutations in Formalin-Fixed Paraffin-Embedded Tissues Using Conventional PCR and Heteroduplex/Amplicon Size Differences

In many families with histories suggestive of BRCA1- or BRCA2-related disease, the proband is deceased. Reliable assessment of archived tissue blocks not amenable to full gene sequencing would be helpful. In this study, a polymerase chain reaction (PCR) assay using primers that bracket the BRCA muta...

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Detalhes bibliográficos
Main Authors: Mangold, Kathy A., Wang, Vivien, Weissman, Scott M., Rubinstein, Wendy S., Kaul, Karen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Technical Advances
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797714/
https://ncbi.nlm.nih.gov/pubmed/19959799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2010.090023
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