Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets

OBJECTIVE: In type 2 diabetes, chronic hyperglycemia is detrimental to β-cells, causing apoptosis and impaired insulin secretion. The transcription factor cAMP-responsive element–binding protein (CREB) is crucial for β-cell survival and function. We investigated whether prolonged exposure of β-cells...

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Bibliografiska uppgifter
Huvudupphovsmän: Costes, Safia, Vandewalle, Brigitte, Tourrel-Cuzin, Cécile, Broca, Christophe, Linck, Nathalie, Bertrand, Gyslaine, Kerr-Conte, Julie, Portha, Bernard, Pattou, François, Bockaert, Joel, Dalle, Stéphane
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2009
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671045/
https://ncbi.nlm.nih.gov/pubmed/19223597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0926
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