Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets

The ubiquitin/proteasome system (UPS), a major cellular protein degradation machinery, plays key roles in the regulation of many cell functions. Glucotoxicity mediated by chronic hyperglycaemia is detrimental to the function and survival of pancreatic beta cells. The aim of our study was to determin...

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Detalhes bibliográficos
Main Authors: Broca, Christophe, Varin, Elodie, Armanet, Mathieu, Tourrel-Cuzin, Cécile, Bosco, Domenico, Dalle, Stéphane, Wojtusciszyn, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958412/
https://ncbi.nlm.nih.gov/pubmed/24642635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092066
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