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Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets

The ubiquitin/proteasome system (UPS), a major cellular protein degradation machinery, plays key roles in the regulation of many cell functions. Glucotoxicity mediated by chronic hyperglycaemia is detrimental to the function and survival of pancreatic beta cells. The aim of our study was to determin...

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Bibliografiske detaljer
Main Authors: Broca, Christophe, Varin, Elodie, Armanet, Mathieu, Tourrel-Cuzin, Cécile, Bosco, Domenico, Dalle, Stéphane, Wojtusciszyn, Anne
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958412/
https://ncbi.nlm.nih.gov/pubmed/24642635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092066
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