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Proteasome Dysfunction Mediates High Glucose-Induced Apoptosis in Rodent Beta Cells and Human Islets

The ubiquitin/proteasome system (UPS), a major cellular protein degradation machinery, plays key roles in the regulation of many cell functions. Glucotoxicity mediated by chronic hyperglycaemia is detrimental to the function and survival of pancreatic beta cells. The aim of our study was to determin...

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Autors principals: Broca, Christophe, Varin, Elodie, Armanet, Mathieu, Tourrel-Cuzin, Cécile, Bosco, Domenico, Dalle, Stéphane, Wojtusciszyn, Anne
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958412/
https://ncbi.nlm.nih.gov/pubmed/24642635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092066
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