GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

Strategies based on activating GLP-1 receptor (GLP-1R) are intensively developed for the treatment of type 2 diabetes. The exhaustive knowledge of the signaling pathways linked to activated GLP-1R within the β-cells is of major importance. In β-cells, GLP-1 activates the ERK1/2 cascade by diverse pa...

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Detalhes bibliográficos
Main Authors: Quoyer, Julie, Longuet, Christine, Broca, Christophe, Linck, Nathalie, Costes, Safia, Varin, Elodie, Bockaert, Joël, Bertrand, Gyslaine, Dalle, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804357/
https://ncbi.nlm.nih.gov/pubmed/19915011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067207
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