Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-κB pathways

Tylophorine and related natural compounds exhibit potent antitumor activities. We previously showed that PBT-1, a synthetic C9-substituted phenanthrene-based tylophorine (PBT) derivative, significantly inhibits growth of various cancer cells. In this study, we further explored the mechanisms and pot...

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Huvudupphovsmän: Lin, Jau-Chen, Yang, Shuenn-Chen, Hong, Tse-Ming, Yu, Sung-Liang, Shi, Qian, Wei, Linyi, Chen, Hsuan-Yu, Yang, Pan-Chyr, Lee, Kuo-Hsiung
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670969/
https://ncbi.nlm.nih.gov/pubmed/19284764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801344j
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