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The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium

Mutations in Connexin50 (Cx50) cause cataracts in both humans and mice. The mechanism(s) behind how mutated connexins lead to a variety of cataracts have yet to be fully elucidated. Here, we tested whether the cataract inducing Cx50-S50P mutant interacts with wild-type Connexin43 (Cx43) to form mixe...

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Detalhes bibliográficos
Main Authors: DeRosa, Adam M., Meşe, Gülistan, Li, Leping, Sellitto, Caterina, Brink, Peter R., Gong, Xiaohua, White, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670955/
https://ncbi.nlm.nih.gov/pubmed/19331825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.01.017
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