Psammaplin A as a general activator of cell based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives

The Wnt signaling pathway regulates cell growth and development in metazoans, and is therefore of interest for drug discovery. By screening a library of 5,808 pre-fractionated marine extracts in a cell-based Wnt signaling assay, several signaling activators and inhibitors were observed. LCMS based f...

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Detalhes bibliográficos
Main Authors: McCulloch, Malcolm W.B., Coombs, Gary S., Banerjee, Nikhil, Bugni, Tim S., Cannon, Kendell M., Harper, Mary Kay, Veltri, Charles A., Virshup, David M., Ireland, Chris M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670876/
https://ncbi.nlm.nih.gov/pubmed/19022675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.077
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