Phospholemman regulates cardiac Na(+)/Ca(2+) exchanger by interacting with the exchanger's proximal linker domain

Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser(68), PLM inhibits cardiac Na(+)/Ca(2+) exchanger (NCX1). We previously demonstrated that the cytoplasmic tail of PLM interacts with the proximal intracellular loop (residues 218–358), but not...

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Autores principales: Zhang, Xue-Qian, Wang, JuFang, Carl, Lois L., Song, Jianliang, Ahlers, Belinda A., Cheung, Joseph Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2009
Materias:
Membrane Transporters, Ion Channels, and Pumps
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670646/
https://ncbi.nlm.nih.gov/pubmed/19158404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00196.2008
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