Substrate Selectivity of 5-Hydroxyeicosanoid Dehydrogenase and Its Inhibition by 5-Hydroxy-Δ(6)-Long-Chain Fatty Acids

5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) is a metabolite of the 5-lipoxygenase (5-LO) product 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE), formed by the microsomal enzyme 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-oxo-ETE is a chemoattractant for neutrophils and eosinophi...

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Autors principals: Patel, Pranav, Cossette, Chantal, Anumolu, Jaganmohan R., Erlemann, Karl-Rudolf, Grant, Gail E., Rokach, Joshua, Powell, William S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Inflammation, Immunopharmacology, and Asthma
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670600/
https://ncbi.nlm.nih.gov/pubmed/19164464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.143453
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