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In Vivo Tumor Targeting and Imaging with Engineered Trivalent Antibody Fragments Containing Collagen-Derived Sequences

There is an urgent need to develop new and effective agents for cancer targeting. In this work, a multivalent antibody is characterized in vivo in living animals. The antibody, termed “trimerbody”, comprises a single-chain antibody (scFv) fragment connected to the N-terminal trimerization subdomain...

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Bibliografiske detaljer
Main Authors: Cuesta, Ángel M., Sánchez-Martín, David, Sanz, Laura, Bonet, Jaume, Compte, Marta, Kremer, Leonor, Blanco, Francisco J., Oliva, Baldomero, Álvarez-Vallina, Luis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670539/
https://ncbi.nlm.nih.gov/pubmed/19401768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005381
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