Integrated Genome-wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemo-resistance in Ovarian Carcinomas

PURPOSE: A significant number of women with serous ovarian cancer are intrinsically refractory to platinum-taxol based treatment. We analyzed somatic DNA copy number variation (CNV) and gene expression data to identify key mechanisms associated with primary resistance in advanced-stage serous cancer...

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Main Authors: Etemadmoghadam, Dariush, deFazio, Anna, Beroukhim, Rameen, Mermel, Craig, George, Joshy, Getz, Gaddy, Tothill, Richard, Okamoto, Aikou, Raeder, Maria B, Harnett, Paul, Lade, Stephen, Akslen, Lars A, Tinker, Anna, Locandro, Bianca, Alsop, Kathryn, Chiew, Yoke-Eng, Traficante, Nadia, Fereday, Sian, Johnson, Daryl, Fox, Stephen, Sellers, William, Urashima, Mitsuyoshi, Salvesen, Helga B, Meyerson, Matthew, Bowtell, David
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670486/
https://ncbi.nlm.nih.gov/pubmed/19193619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1564
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