Nalaganje...
New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ(2) receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents
A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs were synthesized. Among them, WC-26 and WC-59 were identified as the most potent σ(2) receptor ligands (K(i) = 2.58 and 0.82 nM, respectively) with high selectivity against σ(1) (K(i) of σ(1)/σ(2) ratio = 557 and 2,087,...
Shranjeno v:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670245/ https://ncbi.nlm.nih.gov/pubmed/19119012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.025 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|