New N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as σ(2) receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents

A series of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs were synthesized. Among them, WC-26 and WC-59 were identified as the most potent σ(2) receptor ligands (K(i) = 2.58 and 0.82 nM, respectively) with high selectivity against σ(1) (K(i) of σ(1)/σ(2) ratio = 557 and 2,087,...

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Main Authors: Chu, Wenhua, Xu, Jinbin, Zhou, Dong, Zhang, Fanjie, Jones, Lynne A., Wheeler, Kenneth T., Mach, Robert H.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670245/
https://ncbi.nlm.nih.gov/pubmed/19119012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.025
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