Distinct Nucleotide Binding/Hydrolysis Properties and Molar Ratio of MutSα and MutSβ Determine Their Differential Mismatch Binding Activities

MutSα (MSH2/MSH6) and MutSβ (MSH2/MSH3) are eukaryotic mismatch recognition proteins that preferentially process base-base and small insertion/deletion (ID) mispairs, respectively, despite the fact that cells contain a MutSα:MutSβ ratio of 10:1. To explore the mechanism underlying the differential m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tian, Lei, Gu, Liya, Li, Guo-Min
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670160/
https://ncbi.nlm.nih.gov/pubmed/19228687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900908200
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