Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

Cerebellar granule cells from sphingosine 1-phosphate (S1P) lyase-deficient mice were used to study the toxicity of this potent sphingolipid metabolite in terminally differentiated postmitotic neurons. Based on earlier findings with the lyase-stable, semi-synthetic, cis-4-methylsphingosine phosphate...

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Main Authors: Hagen, Nadine, Van Veldhoven, Paul P., Proia, Richard L., Park, Hyejung, Merrill, Alfred H., van Echten-Deckert, Gerhild
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670140/
https://ncbi.nlm.nih.gov/pubmed/19251691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807336200
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