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The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction

The receptor tyrosine kinase c-Kit plays a critical role in hematopoiesis, and gain-of-function mutations of the receptor are frequently seen in several malignancies, including acute myeloid leukemia, gastrointestinal stromal tumors, and testicular carcinoma. The most common mutation of c-Kit in the...

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Bibliografische gegevens
Hoofdauteurs: Sun, Jianmin, Pedersen, Malin, Rönnstrand, Lars
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670109/
https://ncbi.nlm.nih.gov/pubmed/19265199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808058200
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