Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant

Cetuximab and panitumumab efficacy in metastatic colorectal cancer (mCRC) may be influenced by EGFR gene status and/or deregulation of its downstream signalling proteins detected in primary tumour. However, metastasis might have different molecular patterns with respect to primary tumour, possibly a...

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Autores principales: Molinari, F, Martin, V, Saletti, P, De Dosso, S, Spitale, A, Camponovo, A, Bordoni, A, Crippa, S, Mazzucchelli, L, Frattini, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
Materias:
Molecular Diagnostics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669991/
https://ncbi.nlm.nih.gov/pubmed/19293803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604848
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