Inhibition of androstenediol-dependent LNCaP tumour growth by 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235)

Androst-5-ene-3β, 17β-diol (AED) is an adrenal hormone that has been reported to sustain prostate cancer growth after androgen deprivation therapy (ADT). LNCaP cells express a mutated androgen receptor that confers the ability to respond not only to androgen but also to oestrogen and adrenal hormone...

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Bibliographic Details
Main Authors: Trauger, R, Corey, E, Bell, D, White, S, Garsd, A, Stickney, D, Reading, C, Frincke, J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669987/
https://ncbi.nlm.nih.gov/pubmed/19337256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604987
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