17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease

17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP...

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Detalhes bibliográficos
Main Authors: Nicoletti, Ferdinando, Philippens, Ingrid, Fagone, Paolo, Ahlem, Clarence N., Reading, Christopher L., Frincke, James M., Auci, Dominick L.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463191/
https://ncbi.nlm.nih.gov/pubmed/23050197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/969418
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