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Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5′ UTR that is out-of-frame with the main coding sequence. Although uORFs are present in approximately half of human and mouse transcripts, no study has investigated their global impact on protein expression. Here, we report tha...

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Detalhes bibliográficos
Main Authors: Calvo, Sarah E., Pagliarini, David J., Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669787/
https://ncbi.nlm.nih.gov/pubmed/19372376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810916106
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