The Cleavage Products of Amyloid-β Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites

The amyloid-β (Aβ) precursor protein (APP), a transmembrane protein that undergoes proteolytic cleavage into defined fragments, has been implicated in axonal transport. The proposed role of APP as a vesicle receptor for the microtubule motor kinesin-1 has relevance for the pathogenesis of Alzheimer&...

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Main Authors: Muresan, Virgil, Varvel, Nicholas H., Lamb, Bruce T., Muresan, Zoia
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669751/
https://ncbi.nlm.nih.gov/pubmed/19295161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2558-08.2009
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