Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene. All three genetic lesions are potentially pro-angiogenic, as they sustain production of vascular endothelial growth factor (VEGF). Yet Kras-transformed mouse colonocytes lacking p5...

Full description

Saved in:
Bibliographic Details
Main Authors: Dews, Michael, Homayouni, Asal, Yu, Duonan, Murphy, Danielle, Sevignani, Cinzia, Wentzel, Erik, Furth, Emma E, Lee, William M, Enders, Greg H, Mendell, Joshua T, Thomas-Tikhonenko, Andrei
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669546/
https://ncbi.nlm.nih.gov/pubmed/16878133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1855
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items