Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation

Methionine aminopeptidase-2 (MetAP-2) inhibitors have potent anti-angiogenesis activity and are being developed for the treatment of solid tumours. The recently observed specific expression of MetAP-2 in germinal centre B cells suggests that it has a role in regulating B cell function. We have demon...

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Bibliographic Details
Main Authors: Priest, R C, Spaull, J, Buckton, J, Grimley, R L, Sims, M, Binks, M, Malhotra, R
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669528/
https://ncbi.nlm.nih.gov/pubmed/19068103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03843.x
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