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Synthesis of Barbiturate-Based Methionine Aminopeptidase-1 Inhibitors
The syntheses of a new class of barbiturate-based inhibitors for human and E. Coli Methionine Aminopeptidase -1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390822/ https://ncbi.nlm.nih.gov/pubmed/18343108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.02.066 |
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