Novel Bis-(arylsulfonamide) hydroxamate-Based Selective MMP Inhibitors

A series of bis-(arylsulfonamide) hydroxamate inhibitors were synthesized. These compounds exhibit good potency against MMP-7 and MMP-9 depending on the nature, steric bulk and substitution pattern of the substituents in the benzene ring. In general, the preliminary structure-activity relationships...

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Main Authors: Subramaniam, Rajesh, Haldar, Manas K., Tobwala, Shakila, Ganguly, Bratati, Srivastava, D. K., Mallik, Sanku
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490768/
https://ncbi.nlm.nih.gov/pubmed/18442906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.035
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