Balance of Irgm protein activities determines IFN-γ-induced host defense

The immunity-related GTPases (IRG), also known as p47 GTPases, are a family of proteins that are tightly regulated by IFNs at the transcriptional level and serve as key mediators of IFN-regulated resistance to intracellular bacteria and protozoa. Among the IRG proteins, loss of Irgm1 has the most pr...

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Autori principali: Henry, Stanley C., Daniell, Xiaoju G., Burroughs, Ashley R., Indaram, Maanasa, Howell, David N., Coers, Jörn, Starnbach, Michael N., Hunn, Julia P., Howard, Jonathan C., Feng, Carl G., Sher, Alan, Taylor, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Society for Leukocyte Biology 2009
Soggetti:
Host Defense and Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669409/
https://ncbi.nlm.nih.gov/pubmed/19176402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1008599
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