IFN-γ-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo

It has been reported that 4-1BB triggering in vivo selectively suppressed the recall response of staphylococcal enterotoxin A (SEA)-specific CD4(+) T cells, in which CD8(+) T-derived TGF-β was involved. Here, we have examined an alternative mechanism for the 4-1BB-mediated CD4(+) T suppression, as t...

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Bibliografiske detaljer
Main Authors: Kim, Young H., Choi, Beom K., Kang, Woo J., Kim, Kwang H., Kang, Sang W., Mellor, Andrew L., Munn, David H., Kwon, Byoung S.
Format: Artigo
Sprog:Inglês
Udgivet: The Society for Leukocyte Biology 2009
Fag:
Inflammation, Extracellular Mediators, and Effector Molecules
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669405/
https://ncbi.nlm.nih.gov/pubmed/19218483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0408246
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