Unconventional ligand activation of herpesvirus entry mediator signals cell survival

The herpesvirus entry mediator (HVEM; TNFRSF14) activates NF-κB through the canonical TNF-related cytokine LIGHT, serving as a costimulatory pathway during activation of T cells. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160, both of wh...

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Bibliografiske detaljer
Main Authors: Cheung, Timothy C., Steinberg, Marcos W., Oborne, Lisa M., Macauley, Matthew G., Fukuyama, Satoshi, Sanjo, Hideki, D'Souza, Claire, Norris, Paula S., Pfeffer, Klaus, Murphy, Kenneth M., Kronenberg, Mitchell, Spear, Patricia G., Ware, Carl F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669392/
https://ncbi.nlm.nih.gov/pubmed/19332782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902115106
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