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Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains

BACKGROUND: Immature bone marrow B cells are known to have longer CDR3 than mature peripheral B cells, and this genetic characteristic has been shown to correlate with autoreactivity in these early cells. B-cell Central tolerance eliminates these cells, but it is known that autoreactive B cells neve...

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Autori principali: Volpe, Joseph M, Kepler, Thomas B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669064/
https://ncbi.nlm.nih.gov/pubmed/19250530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-7580-5-1
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