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Common Mitochondrial DNA Mutations generated through DNA-mediated Charge Transport

Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)(2)bpy]Cl(3) (phi = 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to allow the complex to enter the cell and bind m...

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Détails bibliographiques
Auteurs principaux: Merino, Edward J., Davis, Molly L., Barton, Jacqueline K.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668510/
https://ncbi.nlm.nih.gov/pubmed/19128037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801570j
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