Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice

Following circulation of avian influenza H5 and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter. We investigated whether these features play a role in the pathogenesis of infection in mammalian hosts. From 199...

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Autores principales: Matsuoka, Yumiko, Swayne, David E., Thomas, Colleen, Rameix-Welti, Marie-Anne, Naffakh, Nadia, Warnes, Christine, Altholtz, Melanie, Donis, Ruben, Subbarao, Kanta
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668507/
https://ncbi.nlm.nih.gov/pubmed/19225004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01987-08
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