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Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities
Cytoplasmic viral RNAs with 5′ triphosphates (5′ppp) are detected by the RNA helicase RIG-I, initiating downstream signaling and alpha/beta interferon (IFN-α/β) expression that establish an antiviral state. We demonstrate here that the hepatitis C virus (HCV) 3′ untranslated region (UTR) RNA has gre...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668486/ https://ncbi.nlm.nih.gov/pubmed/19224987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02449-08 |
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