Knockdown of Ron Kinase Inhibits Mutant Phosphatidylinositol 3-Kinase and Reduces Metastasis in Human Colon Carcinoma

Abnormal accumulation and activation of receptor tyrosine kinase Ron (recepteur d'origine nantais) has been demonstrated in a variety of primary human cancers. We show that RNA interference-mediated knockdown of Ron kinase in a highly tumorigenic colon cancer cell line led to reduced proliferat...

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Détails bibliographiques
Auteurs principaux: Wang, Jing, Rajput, Ashwani, Kan, Julie L. C., Rose, Rebecca, Liu, Xiao-Qiong, Kuropatwinski, Karen, Hauser, Jennie, Beko, Alexander, Dominquez, Ivan, Sharratt, Elizabeth A., Brattain, Lisa, LeVea, Charles, Sun, Feng-Lei, Keane, David M., Gibson, Neil W., Brattain, Michael G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667777/
https://ncbi.nlm.nih.gov/pubmed/19224914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809551200
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