The MPH1 Gene of Saccharomyces cerevisiae Functions in Okazaki Fragment Processing

Saccharomyces cerevisiae MPH1 was first identified as a gene encoding a 3′ to 5′ DNA helicase, which when deleted leads to a mutator phenotype. In this study, we isolated MPH1 as a multicopy suppressor of the dna2K1080E helicase-negative lethal mutant. Purified Mph1 stimulated the endonuclease activ...

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Main Authors: Kang, Young-Hoon, Kang, Min-Jung, Kim, Jeong-Hoon, Lee, Chul-Hwan, Cho, Il-taeg, Hurwitz, Jerard, Seo, Yeon-Soo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667725/
https://ncbi.nlm.nih.gov/pubmed/19181670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808894200
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