Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
Virally transduced genes are often silenced after integration into the host genome. Chromatin immunoprecipitation and nuclease sensitivity experiments now demonstrate that silencing of the transgene is characterized by deacetylation of histone H4 lysines and chromatin condensation. Trichostatin A tr...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26671/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.377 |
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