Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
Virally transduced genes are often silenced after integration into the host genome. Chromatin immunoprecipitation and nuclease sensitivity experiments now demonstrate that silencing of the transgene is characterized by deacetylation of histone H4 lysines and chromatin condensation. Trichostatin A tr...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26671/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.377 |
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