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B2 RNA and Alu RNA repress transcription by disrupting contacts between RNA polymerase II and promoter DNA within assembled complexes

Noncoding RNAs (ncRNAs) are now recognized as transregulators of eukaryotic transcription, a role once attributed exclusively to protein factors. Two ncRNAs in mammalian cells have been shown to repress general mRNA transcription by RNA polymerase II (Pol II) in response to heat shock: mouse B2 RNA...

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Bibliographic Details
Main Authors: Yakovchuk, Petro, Goodrich, James A., Kugel, Jennifer F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667051/
https://ncbi.nlm.nih.gov/pubmed/19307572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810738106
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