Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial

Chemoprevention by isothiocyanates from cruciferous vegetables occurs partly through up-regulation of phase-II conjugating enzymes, such as UDP-glucuronosyl-transferases (UGT). UGT1A1 glucuronidates bilirubin, estrogens, and several dietary carcinogens. The UGT1A1*28 polymorphism reduces transcripti...

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Detalhes bibliográficos
Main Authors: Navarro, Sandi L., Peterson, Sabrina, Chen, Chu, Makar, Karen W., Schwarz, Yvonne, King, Irena B, Li, Shuying S., Li, Lin, Kestin, Mark, Lampe, Johanna W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666928/
https://ncbi.nlm.nih.gov/pubmed/19336732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-08-0178
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