The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa

BACKGROUND: The drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including non-human primates. All Europeans and Asians tested have been shown to be homozygous for a nonfunctional variant, FMO2*2A, which contains a...

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Main Authors: Veeramah, Krishna R., Thomas, Mark G., Weale, Michael E., Zeitlyn, David, Tarekegn, Ayele, Bekele, Endashaw, Mendell, Nancy R., Shephard, Elizabeth A., Bradman, Neil, Phillips, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666332/
https://ncbi.nlm.nih.gov/pubmed/18794725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283097311
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