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The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel β(1) subunit is a lithocholate sensor
Bile acids and other steroids modify BK channel activity contributing to nongenomic modulation of myogenic tone. The protein regions that sense steroid action, however, remain unknown. Accessory BK β(1) subunits are necessary for lithocholate to activate BK channels and vasodilate. Using recombinant...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665905/ https://ncbi.nlm.nih.gov/pubmed/18242174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.01.036 |
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