Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts

Cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. Fibroblasts are activated by factors such as transforming growth factor β and inhibited by agents that elevate 3′,5′-cyclic adenosine monophosphate (cAMP) levels. cAMP sign...

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Hlavní autoři: Liu, Xiaoqiu, Thangavel, Muthusamy, Sun, Shu Qiang, Kaminsky, Joseph, Mahautmr, Penden, Stitham, Jeremiah, Hwa, John, Ostrom, Rennolds S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665709/
https://ncbi.nlm.nih.gov/pubmed/17934720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-007-0196-0
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